We begin this paper briefly exploring the public health crisis of Missing or Murdered Indigenous People (MMIP). Second, we look at the role of culture in prevention through a public health model of primary, secondary, and tertiary prevention and through examples of ACF programs and grantees utilizing culture as prevention. The goal of this this paper is to explore where Tribes can utilize their self-determination to draw on their cultural resources to help protect their members from certain risk factors that can lead to them going missing or being murdered. ANA is actively funding grantees who are conducting projects that use culture as a preventative factor and that are addressing MMIP issues.