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This issue brief summarizes the experiences and wisdom of seven Tribal Maternal, Infant, and Early Childhood Home Visiting (Tribal MIECHV, or Tribal Home Visiting) grantees serving urban Indians.1 It reviews the history of AIAN relocation to urban areas and provides examples of some of the challenges and innovations for meeting the needs of AIAN families in urban areas. These include: (1) helping families ease feelings of isolation by supporting connections to peers and elders; (2) empowering families by leveraging tribal diversity; (3) being flexible in responding to family mobility; and (4) supporting families to access safety-net supports.