The Health Profession Opportunity Grants (HPOG) Program was established by the Affordable Care Act of 2010 (ACA) to provide training programs in high-demand health care professions to Temporary Assistance for Needy Families (TANF) recipients and other low-income individuals. Beginning in 2010, the Administration for Children and Families (ACF) of the U.S. Department of Health and Human Services (HHS) provided five-year grants to 32 grantees in 23 states across the United States. HPOG grantees include post-secondary educational institutions, workforce investment boards (WIBs), state or local government agencies, and non-profit organizations (NPOs). Five grantees are Tribal organizations. In their first year of funding, HPOG grantees were able to launch their programs and enroll and train substantial numbers of participants. This brief describes the HPOG Program and progress made by grantees in the first year of funding. It also describes the evaluation efforts sponsored by ACF to assess the success of the HPOG Program.