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This brief has two main goals:

  • Describe the features of a well-designed and implemented subgroup analysis that uses a multiple regression framework.
  • Provide an overview of recent methodological developments and alternative approaches to conducting subgroup analyses.

The brief builds on a 2009 meeting of experts convened by the Administration for Children and Families’ Office of Planning, Research, and Evaluation and a corresponding 2012 publication in a special issue of Prevention Science (MacKinnon, Supplee, Kelly, & Barofsky, 2012).